Part:BBa_K5066005:Design

Xpp81Aa1-BmK IT1

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  COMPATIBLE WITH RFC[25]
• 1000
  COMPATIBLE WITH RFC[1000]

Design Notes

The combination of BmK and Xpp creates a mixture of different toxins, acting as a security method to prevent insecticide resistance.

Source

Engineered in GEMS Academy

References

Gu, J. B., Dong, Y. Q., Peng, H. J., & Chen, X. G. (2010). A recombinant AeDNA containing the insect-specific toxin, BmK IT1, displayed an increasing pathogenicity on Aedes albopictus. The American journal of tropical medicine and hygiene, 83(3), 614–623. https://doi.org/10.4269/ajtmh.2010.10-0074

Deng, S. Q., Deng, M. Z., Chen, J. T., Zheng, L. L., & Peng, H. J. (2017). Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 37(6), 750–754. https://doi.org/10.3969/j.issn.1673-4254.2017.06.06

Yu-Mei Xiong, Min-Hua Ling, Zheng-Dao Lan, Da-Cheng Wang, Cheng-Wu Chi, The cDNA sequence of an excitatory insect selective neurotoxin from the scorpion Buthus martensi Karsch,Toxicon,Volume 37,Issue 2,1999,Pages 335-341,ISSN 0041-0101,https://doi.org/10.1016/S0041-0101(98)00176-7.

Wu, J., Wei, L., He, J., Fu, K., Li, X., Jia, L., Wang, R., & Zhang, W. (2021). Characterization of a novel Bacillus thuringiensis toxin active against Aedes aegypti larvae. Acta tropica, 223, 106088. https://doi.org/10.1016/j.actatropica.2021.106088